Journal: Nature Communications

Article Title: Minimally invasive detection of cancer using metabolic changes in tumor-associated natural killer cells with Oncoimmune probes

doi: 10.1038/s41467-022-32308-x

Figure Lengend Snippet: a Schematic representation of multiphoton ionization resulting in the formation of intricate 3D nickel nano network of the Oncoimmune probe platform. b High-resolution scanning electron microscopy (HRSEM) image of the OncoImmune probe platform demonstrating 3D networks of the probes generating maze-like sensing platform. Scale bar = 200 nm. c High-resolution transmission electron microscopy (HRTEM) demonstrating the small size of the probes. Scale bar = 5 nm ( d ) energy dispersive x-ray spectroscopy (EDX) showed the presence of nickel and nickel oxide-based probes in the Oncoimmune platform. e Probe size distribution frequency. Samples n = 100 independent particles. For particle size calculation, 100 independent particles were measured, and five independent experiments were performed. f Raman spectra demonstrating the presence of nickel and nickel oxide peaks. Raman measurements were taken 10 times and averaged.

Article Snippet: Scale bar = 5 nm ( d ) energy dispersive x-ray spectroscopy (EDX) showed the presence of nickel and nickel oxide-based probes in the Oncoimmune platform. e Probe size distribution frequency.

Techniques: Electron Microscopy, Transmission Assay, Spectroscopy